Most of our lights are now CFLs. Installing filters where necessary still allows virtually 100% reliability under X10 control.
There are high-end thermostats that offer X10 control. Tied in with motion sensors, that could give you the option to adjust the programmed settings as people move around. However, that may not work as you want due to the thermal lag in such a system.
For a similar investment, you might consider one of the multi-zone control systems available from the HVAC manufacturers. We have the Bryant 8-zone system here. While not capable of integrating with X10 motion sensors, it provides multiple settings at each zone every day. So, it can be programmed with your lifestyle to control only those areas that are normally used during that portion of the day.
A third option is to use a high-end controller, such as the Ocelot, Stargate, or HomeVison, to actually monitor temperatures in each room, and write your own control algorithms. Of course, those sensors would be hardwired. We monitor inside and outside temperatures, and control auxiliary ventilation to pull in the cooler early morning air when the daytime temperatures are hot.
Jeff