I have 2 panels and a sub panel in my shop 100+ ft away. I have a single XTB-IIR that connects to one panel. The underground power box is on my property, so the run from one panel to the other (through the box) is around 50ft. The sub panel is off the second box so the XTB-IIR handles signals from around 150' of wire through 2 panels and I don't see any issues. Granted, I only have 1 X10 light switch and a mini controller in my shop, but it still works 100%. I can't say anything about your setup though.