I just had this problem and discovered via Rodger1818 that PR511's issue block commands if you have more than 1 switch turned on.
See the thread for CM15A No Macro Trigger. In a nutshell here is the conclusion:
So if you have +1 and +2 etc. then a PR511 addressed at A1 issues A3, A4, AON as a sequence. The problem is
that a macro addresses at A3ON will NOT Trigger, because the smart macros require an address followed immediatly
by a command, in the above case, a macro at A4ON will trigger. This could be your problem, since obviously it worked
before smart macros so it's not a noise problem, unless you have added items to your line that are generating new noise.
Test by setting just +1 and put your macro there and see if it triggers.