I haven't actually used a Harmony remote.
I think some of the keys would feel a bit more comfortable if the Nstinct was slightly narrower.
I think the color makes the icon look less "cheap" and the white buttons on the Nstinct are a big part in why it looks cheaper for me.
The side buttons I actually prefer on the Nstinct even though they are a harder plastic and not a softer rubberized button like the Icon.
For a $30 remote though, I can't complain too much.
The Nstinct is easily worth $30 to me.
I also REALLY wish they had left the mini USB connector a part of the remote and allowed firmware updates for any fixes and channel icon updates for new channels, as well as a backup of your settings that would allow you to "clone" to any additional x10 icon type remotes you may own.