In addition to total load current and signal attenuation with that many modules, another concern is switching them off. If configured is series as you specify, the order must be reversed when switching them off. And while we can achieve a high level of reliability, it will never be 100%. So if on occasion one of the modules does not switch on, everything beyond that would not respond either. The switching sequence must be reversed when turning off, and it is possible that one might not respond to the off command too.
A better arrangement would be to run several independent circuits fed by a common subpanel. Each circuit would feed up to a dozen modules wired in parallel, and all modules would receive commands, not just the ones earlier in the string. That allows redundant commands to be issued to increase reliability.
Multiple circuits also reduce signal loading so the distant modules would receive stronger signals. But if the run length is much over 100 feet, you may have to consider a signal booster to insure adequate signal strength at the distant locations.
Wiring in parallel also eases the control. A single ALL_OFF command can extinguish up to 16 sets of lights. And you can use the "arming" process A1, A2, A3, A4, A5, A_ON to turn on sets 1-5 at the same time. Of course, you can also use A1, A_ON, A2, A_ON, A3, A_ON, … in sequence if you prefer the sets of lights to switch on one-by-one.
Jeff