I'm using a Boston Acoustics/Philips TSU501, which is similar to a Philips ProntoNEO TSU500 with extra hard buttons, a tilt sensor, RF extendability, and a nicer shape and feel. To control my X10 devices, it sends RF to a Philips RFX6500 RF extender (via an antenna in the attic) which converts it to IR, which goes to an IR543 into which I've installed the Laser IRAH kit for all-housecode control (so it's now an IR543AH). I had to do some binary-level hacking to get the extra IRAH house codes into my remote since I couldn't find them for the TSU500/TSU501 formats. It was worth it because I now have a very customizable remote with a touchscreen and lots of hard buttons controlling all my X10 devices as well as nearly every other device in my house.
This is another example of how, with a little bit of work, X10 is compatible with everything!