The Nstinct remote does not feature "State Memory" which is a function of the Harmony (and some other) remotes. It was not designed to remember whether or not the TV was left on and what channel/input it was set to, etc. As such, you will have to turn your devices on manually using the "QuickPower" feature, and then set them to the appropriate inputs as well. Where the Nstinct does shine is in it's ability to control a variety of devices, and still talk to your X10 Modules over RF (requires a transceiver like the TM751 or RR501 to work). With RF functions built in to the remote, it enables you to control a lot more without having to set up an extra box.
If you wanted to use your Harmony with X10, you would need an IR543 and patience to program it manually. Hence, the need for the Nstinct, ready to play with AV and X10
EDIT: There is a way to turn on multiple items with a single button press at least, partially there to what you wanted:
http://kbase.x10.com/wiki/IR_Learning_with_iconRemote#Macros